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[DOI] [PubMed] [Google Scholar] 115.Higdon J.V., Delage B., Williams D.E., Dashwood R.H

Nielsen, J., & Keasling, J

Researchers have also explored DSIPs possible role in stress regulation, hormone signaling, and pain modulation, but the overall evidence remains preliminary and insufficient for definitive clinical recommendations

Glio- and neuro-protection by prosaposin is mediated by orphan G-protein coupled receptors GPR37L1 and GPR37

Furthermore, aloe-emodin exhibits anti-cancer activity against NSCLC (A549 and NCI-H1299) through Caspase-dependent apoptosis, autophagy induction via MAPK activation and AKT/mTOR inhibition, and ROS-mediated autophagy-triggered apoptosis, demonstrating its potential as a therapeutic candidate and synergize with gemcitabine [505]